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1

Novel caffeic acid derivatives: extremely potent inhibitors of 12-lipoxygenase

Cho, Hidetsura, Ueda, Masaru, Tamaoka, Mie, Hamaguchi, Mikiko, Aisaka, Kazuo, Kiso, Yoshinobu, Inoue, Teruyoshi, Ogino, Ryoko, Tatsuoka, Toshio

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 388 KB

english, 1991

2

Discovery of Novel Tetrahydroisoquinoline Derivatives as Potent and Selective Factor Xa Inhibitors.

Hiroshi Ueno, Katsuyuki Yokota, Jun-ichi Hoshi, Katsutaka Yasue, Mikio Hayashi, Itsuo Uchida, Kazuo Aisaka, Yasunori Hase, Susumu Katoh, Hidetsura Cho

Journal:

Year:

2005

File:

PDF, 13 KB

2005

3

Structure–activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa

Hiroshi Ueno, Susumu Katoh, Katsuyuki Yokota, Jun-ichi Hoshi, Mikio Hayashi, Itsuo Uchida, Kazuo Aisaka, Yasunori Hase, Hidetsura Cho

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 325 KB

english, 2004

4

Discovery of novel tetrahydroisoquinoline derivatives as potent and selective factor Xa inhibitors

Hiroshi Ueno, Katsuyuki Yokota, Jun-ichi Hoshi, Katsutaka Yasue, Mikio Hayashi, Itsuo Uchida, Kazuo Aisaka, Yasunori Hase, Susumu Katoh, Hidetsura Cho

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 374 KB

english, 2005

5

Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690

Hiroyuki Uchida, Daisaku Kondo, Ayako Yamashita, Yukio Nagaosa, Takeshi Sakurai, Yutaka Fujii, Kinya Fujishiro, Kazuo Aisaka, Takayuki Uwajima

Journal:

FEMS Microbiology Letters

Year:

2003

Language:

english

File:

PDF, 261 KB

english, 2003

6

Contractile properties of urethral smooth muscles of young and aged female dogs: Morphological and pharmacological aspects

Helen Ahmed, Nobuo Moriyama, Ritsu Fukasawa, Hiroaki Nishimatsu, Yoshinori Tanaka, Tadaichi Kitamura, Satoshi Tatemichi, Katsuyoshi Akiyama, Yasunori Suzuki, Kazuo Aisaka

Journal:

International Journal of Urology

Year:

2000

Language:

english

File:

PDF, 1003 KB

english, 2000

7

Modeling the anti-CEA antibody combining site by homology and conformational search

Maria T. Mas, Kenneth C. Smith, David L. Yarmush, Kazuo Aisaka, Richard M. Fine

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1992

Language:

english

File:

PDF, 1.71 MB

english, 1992

8

Frequency–voltage cooperative CPU power control: A design rule and its application by feedback prediction

Keisuke Toyama, Satoshi Misaka, Kazuo Aisaka, Toshiyuki Aritsuka, Kunio Uchiyama, Koichiro Ishibashi, Hiroshi Kawaguchi, Takayasu Sakurai

Journal:

Systems and Computers in Japan

Year:

2005

Language:

english

File:

PDF, 780 KB

english, 2005

9

Optimum culture conditions for the epoxidation ofcis-propenylphosphonate to fosfomycin byCellvibrio gilvus

Kazuo Aisaka, Takashi Ohshiro, Takayuki Uwajima

Journal:

Applied Microbiology and Biotechnology

Year:

1992

Language:

english

File:

PDF, 519 KB

english, 1992

10

Hyperproduction of N-acetylneuraminate lyase by the gene-cloned strain ofEscherichia coli

Kazuo Aisaka, Shigeaki Tamura, Yuko Arai, Takayuki Uwajima

Journal:

Biotechnology Letters

Year:

1987

Language:

english

File:

PDF, 218 KB

english, 1987

11

Purification and Some Properties of An Aldehyde Oxidase fromStreptomyces RimosusATCC10970

Hiroyuki Uchida, Yoshimasa Okamura, Hiroki Yamanaka, Tetsuya Fukuda, Sachie Haneda, Kazuo Aisaka, Yutaka Fujii

Journal:

World Journal of Microbiology and Biotechnology

Year:

2006

Language:

english

File:

PDF, 257 KB

english, 2006

12

Production of neuraminidase by Micromonospora viridifaciens

Kazuo Aisaka, Takayuki Uwajima

Journal:

FEMS Microbiology Letters

Year:

1987

Language:

english

File:

PDF, 203 KB

english, 1987

13

Production of trehalose phosphorylase by Catellatospora ferruginea

Kazuo Aisaka, Tomomi Masuda

Journal:

FEMS Microbiology Letters

Year:

1995

Language:

english

File:

PDF, 398 KB

english, 1995

14

Purification and properties of a new Brevibacterium sterolicum cholesterol oxidase produced by E. coli MM294/pnH10

Kinya Fujishiro, Hiroyuki Uchida, Kotaro Shimokawa, Maki Nakano, Fumihiko Sano, Toshio Ohta, Norihiko Kayahara, Kazuo Aisaka, Takayuki Uwajima

Journal:

FEMS Microbiology Letters

Year:

2002

Language:

english

File:

PDF, 271 KB

english, 2002

15

Pharmacological profiles of a novel opioid receptor-like1 (ORL1) receptor antagonist, JTC-801

Hideki Yamada, Hiromitsu Nakamoto, Yasunori Suzuki, Takao Ito, Kazuo Aisaka

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 276 KB

english, 2002

16

Distribution of α1L-Adrenoceptors in Canine Prostate: Characterization by Quantitative Autoradiography

YASUNORI SUZUKI, NOBUO MORIYAMA, YUKI OKAYA, ATSUNORI KANADA, HIROAKI NISHIMATSU, KAZUKI KAWABE, KAZUO AISAKA

Journal:

Journal of Pharmacy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 417 KB

english, 2000

17

Synthesis and Structure−Activity Relationships of Novel Selective Factor Xa Inhibitors with a Tetrahydroisoquinoline Ring

Uchida, Itsuo, Aisaka, Kazuo, Katoh, Susumu, Cho, Hidetsura, Ueno, Hiroshi, Yokota, Katsuyuki, Hoshi, Jun-ichi, Yasue, Katsutaka, Hayashi, Mikio, Hase, Yasunori

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 425 KB

english, 2005

18

Properties of maltose phosphorylase from Propionibacterium freudenreichii

Kazuo Aisaka, Tomomi Masuda, Tadashi Chikamune

Journal:

Journal of Fermentation and Bioengineering

Year:

1996

Language:

english

File:

PDF, 329 KB

english, 1996

19

The cannabinoid CB2 receptor inverse agonist JTE-907 suppresses spontaneous itch-associated responses of NC mice, a model of atopic dermatitis

Tatsuya Maekawa, Hiroshi Nojima, Yasushi Kuraishi, Kazuo Aisaka

Journal:

European Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 159 KB

english, 2006

20

Effect of JTH-601, a novel α1-adrenoceptor antagonist, on prostate function in dogs

Yasunori Suzuki, Atsunori Kanada, Yuki Okaya, Kazuo Aisaka

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 242 KB

english, 2000

21

Antithrombotic effects of a synthetic inhibitor of activated factor X, JTV-803, in animals

Mikio Hayashi, Akira Matsuo, Hiromitsu Nakamoto, Kazuo Aisaka

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 174 KB

english, 2001

22

Inhibitory effect of JTV-803, a new cyclic guanidine derivative, on factor Xa in vitro and in vivo

Mikio Hayashi, Atsushi Hamada, Yuki Okaya, Korekiyo Wakitani, Kazuo Aisaka

Journal:

European Journal of Pharmacology

Year:

2001

Language:

english

File:

PDF, 89 KB

english, 2001

23

Effect of JTH-601, a novel α1-adrenoceptor antagonist, on the function of lower urinary tract and blood pressure

Yasunori Suzuki, Atsunori Kanada, Yuki Okaya, Kazuo Aisaka, Ikunobu Muramatsu

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 249 KB

english, 1999

24

Age-related change of the role of α1L-adrenoceptor

Yasunori Suzuki, Nobuo Moriyama, Yuki Okaya, Hiroaki Nishimatsu, Kazuki Kawabe, Kazuo Aisaka

Journal:

General Pharmacology: The Vascular System

Year:

1999

Language:

english

File:

PDF, 3.51 MB

english, 1999

25

Enzymatic synthesis of novel disaccharides using disaccharide phosphorylases

Kazuo Aisaka, Tomomi Masuda-Kato, Tadashi Chikamune, Kazuyo Kamitori, Youichi Uosaki, Yutaka Saito

Journal:

Journal of Bioscience and Bioengineering

Year:

2000

Language:

english

File:

PDF, 737 KB

english, 2000

26

Determination of 1,5-Anhydro-d-glucitol on the basis of its inhibitory effect on trehalase activity

Sakae Tazoe, Tomomi Masuda-Kato, Yoshinori Chikama, Kazuo Aisaka

Journal:

Journal of Bioscience and Bioengineering

Year:

2001

Language:

english

File:

PDF, 314 KB

english, 2001

27

Production of aldehyde oxidases by microorganisms and their enzymatic properties

Yasuhara Akinori, Akiba-Goto Miho, Fujishiro Kinya, Uchida Hiroyuki, Uwajima Takayuki, Aisaka Kazuo

Journal:

Journal of Bioscience and Bioengineering

Year:

2002

Language:

english

File:

PDF, 954 KB

english, 2002

28

L-arginine availability determines the duration of acetylcholine-induced systemic vasodilatation in vivo

Kazuo Aisaka, Steven S. Gross, Owen W. Griffith, Roberto Levi

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 433 KB

english, 1989

29

NG-methylarginine, and inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: Does nitric oxide regulate blood pressure in vivo?

Kazuo Aisaka, Steven S. Gross, Owen W. Griffith, Roberto Levi

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 388 KB

english, 1989

30

Macrophage and endothelial cell nitric oxide synthesis: Cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine

Steven S. Gross, Dennis J. Stuehr, Kazuo Aisaka, Eric A. Jaffe, Roberto Levi, Owen W. Griffith

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 504 KB

english, 1990

31

Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver

Kazuhiro Sakurada, Kazuhisa Uchida, Kazuo Yamaguchi, Kazuo Aisaka, Seiga Ito, Toshihiko Ohmori, Yoshifumi Takeyama, Takashi Ueda, Yuichi Hori, Harumasa Ohyanagi, Yoichi Saitoh, Kozo Kaibuchi, Yoshimi

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 729 KB

english, 1991

32

Anti-heart failure effect of carperitide (SUN 4936) on experimental animals

Kazuo Aisaka, Toshinori Hidaka, Mayumi Furuya, Norio Inomata, Tomoko Miyazaki, Mitsugu Omata, Teruyoshi Inoue, Maki Yoshida, Yoshikazu Hattori, Tomochika Ohno, Takafumi Ishihara, Tadashi Kanai

Journal:

Journal of Molecular and Cellular Cardiology

Year:

1992

Language:

english

File:

PDF, 114 KB

english, 1992

33

Production of trehalose phosphorylase by Catellatospora ferruginea

Kazuo Aisaka, Tomomi Masuda

Journal:

FEMS Microbiology Letters

Year:

1995

Language:

english

File:

PDF, 418 KB

english, 1995

34

The role of α1L-adrenoceptor in rat urinary bladder: Comparison between young adult and aged rats

Yasunori Suzuki, Nobuo Moriyama, Atsunori Kanada, Yuki Okaya, Kazuki Kawabe, Kazuo Aisaka

Journal:

Year:

1999

Language:

english

File:

PDF, 505 KB

english, 1999

35

Effects of activated factor X inhibitor, JTV-803, in a pig model of hemodialysis

Mikio Hayashi, Naofumi Uesato, Kazuo Aisaka

Journal:

Thrombosis Research

Year:

2002

Language:

english

File:

PDF, 304 KB

english, 2002

36

Purification and properties of a new Brevibacterium sterolicum cholesterol oxidase produced by E. coli MM294/pnH10

Kinya Fujishiro, Hiroyuki Uchida, Kotaro Shimokawa, Maki Nakano, Fumihiko Sano, Toshio Ohta, Norihiko Kayahara, Kazuo Aisaka, Takayuki Uwajima

Journal:

FEMS Microbiology Letters

Year:

2002

Language:

english

File:

PDF, 274 KB

english, 2002

37

Dihydropyrimidines: novel calcium antagonists with potent and long-lasting vasodilative and anti-hypertensive activity

Cho, Hidetsura, Ueda, Masaru, Shima, Keiyuu, Mizuno, Akira, Hayashimatsu, Mariko, Ohnaka, Yoshiko, Takeuchi, Yumi, Hamaguchi, Mikiko, Aisaka, Kazuo

Journal:

Journal of Medicinal Chemistry

Year:

1989

Language:

english

File:

PDF, 911 KB

english, 1989

38

Synthesis and Selective Coronary Vasodilatory Activity of 3,4-Dihydro-2,2-bis(methoxymethyl)-2 H -1-benzopyran-3-ol Derivatives: Novel Potassium Channel Openers

Cho, Hidetsura, Katoh, Susumu, Sayama, Shinsuke, Murakami, Kengo, Nakanishi, Hiroyuki, Kajimoto, Yasuyuki, Ueno, Hiroshi, Kawasaki, Hisashi, Aisaka, Kazuo, Uchida, Itsuo

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 342 KB

english, 1996

39

New antiarrhythmic agents. N-Aryl-8-pyrrolizidinealkanamides

Miyano, Seiji, Sumoto, Kunihiro, Satoh, Fumio, Shima, Keiyu, Hayashimatsu, Mariko, Morita, Minoru, Aisaka, Kazuo, Noguchi, Teruhisa

Journal:

Journal of Medicinal Chemistry

Year:

1985

Language:

english

File:

PDF, 554 KB

english, 1985

40

Sequence of gene choB encoding cholesterol oxidase of Brevibacterium sterolicum: comparison with choA of Streptomyces sp. SA-COO

Toshio, Ohta, Kinya, Fujishiro, Kazuo, Yamaguchi, Yoshio, Tamura, Kazuo, Aisaka, Takayuki, Uwajima, Mamoru, Hasegawa

Journal:

Year:

1991

Language:

english

File:

PDF, 471 KB

english, 1991

41

Effects of C-Terminal Deletions on the Conformational State and Denaturation of Phosphoglycerate Kinase

Mas, Maria T., Chen, Hsiu-Hua, Aisaka, Kazuo, Lin, Lung-Nan, Brandts, John F.

Journal:

Year:

1995

Language:

english

File:

PDF, 1.48 MB

english, 1995

42

Cloning and Sequencing of the Aldehyde Oxidase Gene from Methylobacillus sp. KY4400

YASUHARA, Akinori, AKIBA-GOTO, Miho, AISAKA, Kazuo

Journal:

Bioscience Biotechnology and Biochemistry

Year:

2005

Language:

english

File:

PDF, 74 KB

english, 2005

43

Conserved Organization of Genes for Biosynthesis of Chlortetracycline in Streptomyces Strains

Dairi, Tohru, Nakano, Tetsuo, Mizukami, Toru, Aisaka, Kazuo, Hasegawa, Mamoru, Katsumata, Ryoichi

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1995

Language:

english

File:

PDF, 494 KB

english, 1995

44

Nucleotide Sequence of the FAD Synthetase Gene from Corynebacterium ammoniagenes and Its Expression in Escherichia coli

Nakagawa, Satoshi, Igarashi, Akiko, Ohta, Toshio, Hagihara, Takeshige, Fujio, Tatsuro, Aisaka, Kazuo

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1995

Language:

english

File:

PDF, 1.17 MB

english, 1995

45

Cloning and Nucleotide Sequence of the Gene Responsible for Chlorination of Tetracycline

Dairi, Tohru, Nakano, Tetsuo, Aisaka, Kazuo, Katsumata, Ryoichl, Hasegawa, Mamoru

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1995

Language:

english

File:

PDF, 1.34 MB

english, 1995

46

A Self-defense Gene Homologous to Tetracycline Effluxing Gene Essential for Antibiotic Production in Streptomyces aureofaciens

Dairi, Tohru, Aisaka, Kazuo, Katsumata, Ryoichi, Hasegawa, Mamoru

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1995

Language:

english

File:

PDF, 1.06 MB

english, 1995

47

Hyperexpression and Analysis of choB Encoding Cholesterol Oxidase of Brevibacterium sterolicum in Escherichia coli and Streptomyces lividans .

Ohta, Toshio, Fujishiro, Kinya, Yamaguchi, Kazuo, Uwajima, Takayuki, Aisaka, Kazuo, Hasegawa, Mamoru

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1992

Language:

english

File:

PDF, 1.07 MB

english, 1992

48

Purification and Characterization of Trehalose Phosphorylase from Catellatospora ferruginea

AISAKA, Kazuo, MASUDA, Tomomi, CHIKAMUNE, Tadashi, KAMITORI, Kazuyo

Journal:

Bioscience Biotechnology and Biochemistry

Year:

1998

File:

PDF, 880 KB

1998

49

Cardiovascular Pharmacological Studies on JTV-506, a New Potassium Channel Opener 2nd Communication: Effects on blood pressure in conscious animals

Hirata, Yukiya, Suzuki, Yasunori, Miyai, Hisato, Aisaka, Kazuo

Journal:

Arzneimittelforschung

Year:

2011

Language:

english

File:

PDF, 152 KB

english, 2011

50

Pharmacological Actions of Analogues of Feruloylhistamine, an Imidazole Alkaloid of Ephedra Roots 1

Hikino, Hiroshi, Kiso, Yoshinobu, Ogata, Minoru, Konno, Chohachi, Aisaka, Kazuo, Kubota, Hiroaki, Hirose, Nakako, Ishihara, Takafumi

Journal:

Year:

1984

Language:

english

File:

PDF, 249 KB

english, 1984

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